Our laboratory is part of a growing group of stem cell biologists at the University of Texas at San Antonio. We study the stem cell system underlying spermatogenesis which are essential for male fertility. A primary interest of the lab is understanding the fundamental biology of these spermatogonial stem cells, normal male germline development, and how stem cells might be used to regenerate spermatogenesis. We are also actively pursuing approaches to preserve fertility in prepubertal male cancer patients.
G-CSF promotes spermatogenic regeneration from surviving spermatogonia after high-dose alkylating chemotherapy.Epub: Janurary 11, 2017. Print: N/A.
Kotzur T, Benavides-Garcia R, Mecklenburg J, Sanchez J, Reilly R and Hermann BP. 2017. Reproductive Biology and Endocrinology 15:7.
TSPAN8 Expression Distinguishes Spermatogonial Stem Cells in the Prepubertal Mouse Testis.Epub: October 12, 2016. Print: December 1, 2016.
Mutoji K, Singh A, Nguyen T, Gildersleeve H, Kaucher AV, Oatley MJ, Oatley JM, Velte EK, Geyer CB, Cheng K, McCarrey JR and Hermann BP. 2016. Biology of Reproduction 95(6):117, 1–14.
The regulatory repertoire of PLZF and SALL4 in undifferentiated spermatogonia.Epub: April 11, 2016. Print: June 1, 2016.
Lovelace DL, Gao Z, Mutoji KN, Ruan J, and Hermann BP. 2016. Development 143: 1893-1906.
Mechanisms regulating spermatogonial differentiation.Epub: -. Print: 2016.
Mecklenburg JM and Hermann BP. 2016. Results Probl Cell Differ 58:253-87.
Adult Human Mesenchymal Stem Cell Differentiation at the Cell Population and Single-Cell Levels Under Alternating Electric Current.Epub: Dec. 28, 2015. Print: January 27, 2016.
Wechsler ME, Hermann BP, and Bizios R. 2016. Tissue Engineering Part C: Methods 22(2): 155-164.
Granulocyte colony-stimulating factor prevents loss of spermatogenesis after sterilizing busulfan chemotherapy.Epub: Nov. 5, 2014. Print: January 2015.
Benavides-Garcia R*, Joachim R*, Pina N, Mutoji KN, Reilly M, and Hermann BP. *equal contribution. Fertility and Sterility 03(1):270-280.e8.
Hormone suppression with GnRH antagonist promotes spermatogenic recovery from transplanted spermatogonial stem cells in irradiated cynomolgus monkeys.Epub: Sept. 30, 2013. Print: November 2013.
Shetty G, Uthamanthil RK, Zhou W, Shao SH, Weng CC, Tailor RC, Hermann BP, Orwig KE and Meistrich ML. Andrology. 1(6):886-98.
Eliminating malignant contamination from therapeutic human spermatogonial stem cells.Epub: March 15, 2013. Print: April 1, 2013.
Dovey SL, Valli H, Hermann, B.P., Sukhwani M, Donohue J, Castro CA, Chu T, Sanfilippo JS, Orwig KE. Journal of Clinical Investigation. 123(4):1833-43.
Spermatogonial stem cell transplantation into Rhesus testes regenerates spermatogenesis producing functional sperm.Epub: November 2, 2012. Print: November 2012.
Hermann, B.P., Sukhwani, M., Winkler, F. Pascarella, J.N., Peters, K.A., Sheng, Y., Valli, H., Rodriguez, M., Ezzelarab, M., Dargo, G., Peterson, K., Masterson, K., Ramsey, C., Ward, T., Lienesch, M., Volk, A., Cooper, D.K.C., Thomson, A.W., Kiss, J.E., Penedo, M.C.T., Schatten, G.P., Mitalipov, S., and Orwig, K.E. Cell Stem Cell. 11(5): 715-726.
Direct Differentiation of Human Pluripotent Stem Cells into Haploid Spermatogenic Cells.Epub: August 23, 2012. Print: September 2012.
Easley IV, C.A., Phillips, B.T., McGuire, M.M., Barringer, J.M., Valli, H., Hermann, B.P., Simerly, C.R., Rajkovic, A., Miki, T., Orwig, K.E., and Schatten G.P. Cell Reports. 2(3):440-6.
Separating spermatogonia from cancer cells in contaminated prepubertal primate testis cell suspensions.Epub: October 20, 2011. Print: December 2011.
Hermann, B.P., Sukhwani, M., Salati, J., Chu, T., Sheng, Y., and Orwig, K.E. Human Reproduction. 26(12):3222-31.
The elusive spermatogonial stem cell marker?Epub: May 12, 2011. Print: August 2011.
Hermann, B.P., Phillips, B.T., and Orwig, K.E. Biology of Reproduction. 85: 221-3.
Male Germline Stem Cells: Developmental and Regenerative Potential. (Book)Epub: N/A. Print: January 2011.
Orwig, K.E. and Hermann, B.P. (editors) Springer. New York, NY
Translating spermatogonial stem cell transplantation to the clinic. (Book chapter)Epub: N/A. Print: January 2011.
Hermann, B.P. and Orwig, K.E. in Male Germline Stem Cells: Developmental and Regenerative Potential. Orwig, K.E. and Hermann, B.P. (editors) Springer. New York, NY
Spermatogonial stem cells in higher primates: are there differences to those in rodents?Epub: October 30, 2009. Print: March 2010.
Hermann, B.P., Sukhwani, M., Hansel M.C., and Orwig, K.E. Reproduction. 139:479-493.
Molecular dissection of the male germ cell lineage identifies putative spermatogonial stem cells in rhesus macaques.Epub: March 31, 2009. Print: July 2009.
Hermann, B.P., Sukhwani, M., Simorangkir, D., Chu, T., Plant, T., and Orwig, K.E. Human Reproduction. 24(7):1704-16.
In vivo regulation of FSH-receptor (Fshr) by the transcription factors USF1 and USF2 is cell specific.Epub: June 19, 2008. Print: October 2008.
Hermann, B.P., Hornbaker, K., Rice, D.A., Sawadogo, M., and Heckert, L.L. Endocrinology. 149(10):5297-306.
Characterization, cryopreservation, and ablation of spermatogonial stem cells in adult rhesus macaques.Epub: June 21, 2007. Print: September 2007.
Hermann, B.P., Sukhwani, M., Lin, C., Sheng, Y., Tomko, J., Rodriguez, M., Shuttleworth, J., McFarland, D., Hobbs, R.M., Pandolfi, P.P., Schatten, G.P., and Orwig, K.E. Stem cells. 25(9):2330-2338.
Distal regulatory elements are required for Fshr expression, in vivo.Epub: November 9, 2006. Print: January 2007.
Hermann, B.P., Hornbaker, K., Manimaran, R.R., and Heckert, L.L. Molecular and Cellular Endocrinology. 260-262: 49-58.
Transcriptional regulation of the FSH receptor: new perspectives.Epub: November 2, 2006. Print: January 2007.
Hermann, B.P. and Heckert, L.L. Molecular and Cellular Endocrinology. 260-262:100-108.
Silencing of Fshr occurs through a conserved, hypersensitive site in the first intron.Epub: April 7, 2005. Print: August 2005.
Hermann, B.P. and Heckert, L.L. Molecular Endocrinology. 19(8):2112-2131.
Quantitative evaluation of pollen polymorphism in a tristylous weed, Lythrum salicaria (Lythraceae).Epub: N/A. Print: August 2000.
Mal, T.K. and Hermann, B.P.. Canadian Journal of Botany. 78(8): 1086-1094.
Quantitative evaluation of stigma polymorphism in a tristylous weed, Lythrum salicaria (Lythraceae).Epub: N/A. Print: August 1999.
Hermann, B.P. Mal, T.K., Williams, R.J. and Dollahon, N.R. American Journal of Botany. 86 (8): 1121-1129.